Fast pain reduction

SynolisTM is a patented injectable gel containing Hyaluronic Acid and Sorbitol that has the same rheological properties as a healthy joint fluid. Clinical data demonstrates significant pain relief within the first week after treatment with SynolisTM, with effects lasting up to 6 months. 1

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key numbers

Clinical performance

Based on a study of 80mg hyaluronic acid – 160 mg sorbitol on articular pain and mobility associated with gonarthrosis. Results from 93 patients.

Source: Cortet, B., Lombion, S., Naissant, B. et al. Non-Inferiority of a Single Injection of Sodium Hyaluronate Plus Sorbitol to Hylan G-F20: A 6-Month Randomized Controlled Trial. Advances in Therapy 38, 2271–2283 (2021). Read article

61.8 %
of pain relief at 6 months.
78.8 %
of strict responders after 6 months
89.2 %
of patients were satisfied at the 6 month mark
53 %
reduction on the WOMAC Stiffness scale at 1 month

Revolutionising the market

Aptissen launched SynolisTM the first intra-articular injection which combines Hyaluronic Acid (HA) with Sorbitol.


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Research & Scientific Collaborations are the lifeblood of Aptissen. Sharing is in our DNA. We value the benefits of strong strategic collaborations with other experts, such as academic institutions, in the scientific community.

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